Blister agents nitrogen mustard for more detailed recommendations, pdf. Systemic exposure was undetectable in 16 patients who received mechlorethamine 0. Mustargen has been shown to produce fetal malformations in the rat and ferret when given as single subcutaneous injections of 1 mgkg 23 times the maximum recommended human dose. Nitrogen oxides, hydrogen chloride, ammonia andor derivatives are hazardous decomposition products. Ungraded products supplied by spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for. Material safety data sheet of mechlorethamine hydrochloride. Toxic by inhalation, in contact w ith skin and if swallowed. Blister agents nitrogen mustard for more detailed recommendations. Mustargen is also used to treat certain other blood disorders polycythemia vera and is sometimes injected into body spaces, such as the chest. May decompose upon heating to product corrosive andor.
Mechlorethamine is used to treat hodgkins lymphoma hodgkins disease and certain types of nonhodgkins lymphoma types of cancer that begin in a type of white blood cells that normally fights infection. Mechlorethamine structure shown in top panel is the first chemotherapeutic alkylating agent and is an analog of the wwi chemical warfare agent mustard gas. Mechlorethamine hydrochloride, also known as chlormethine, can be used in the synthesis of meperidine. Mechlorethamine was initially developed as a blistering agent for use in chemical warfare but has since exhibited anticancer chemotherapeutic benefit. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Mechlorethamine hcl is a white to off white solid that is very soluble in water and methanol, partially soluble in acetone, and generally not soluble in organic solvents. Mechlorethamine hydrochloride drug information, professional. It is the prototype of alkylating agents, a group of anticancer chemotherapeutic drugs. Used primarily for the treatment of disseminated hodgkins disease, especially in the mopp treatment regimen, and for other lymphomas, including mycosis fungoides. Mechlorethamine hcl is a white to off white solid that is very soluble in water and methanol, partially soluble in acetone, and generally not soluble in organic solvents mechlorethamine hcl is designated chemically as 2chloron2chloroethyln.
Hypersensitivity reactions, including anaphylaxis, have occurred with topical formulations of mechlorethamine. Valchlor is a topical product that contains mechlorethamine hcl, an alkylating drug. Mechlorethamine treats only the symptoms of cancer but does not treat the cancer itself mechlorethamine is also sometimes injected into body spaces around the heart, lungs, or stomach to treat fluid retention in these areas caused by cancer. Mechlorethamine hydrochloride national cancer institute. Mustargen mechlorethamine hydrochloride dose, indications. Valchlor mechlorethamine gel medicine for early mfctcl. Explore information about air pollutants, contaminants and studies being done. Mechlorethamine is the original nitrogen mustard and is still used today in the. National toxicology program ntp report on carcinogens mechlorethamine hydrochloride cas 55867 reasonably anticipated to be a human carcinogen. Mechlorethamine hydrochloride definition of mechlorethamine. Mustargen mechlorethamine hcl is a cancer antineoplastic medication used to treat several types of cancer, such as hodgkins disease, lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, lung cancer and mycosis fungoides.
The most common side effects of mechlorethamine hcl are nausea, vomiting, diarrhea, loss of appetite, dizziness, and skin rashes. Mechlorethamine is a synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Mar 26, 2018 valchlor is a topical product that contains mechlorethamine hcl, an alkylating drug. Drug information on mustargen mechlorethamine includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. Less common and often more severe side effects include pain, redness, or swelling at the area where the drug is injected. Gain reliable data with our mechlorethamine hydrochloride reference standards. Long term stability measurements were made for the nitrogen mustard mechlorethamine hcl at a concentration of 0. Mechlorethamine and halfmustard were undetectable in plasma after 2, 4, or 6 months of treatment with mechlorethamine 0. Dec, 2018 valchlor is a topical product that contains mechlorethamine hcl, an alkylating drug.
It was used in a study to demonstrate the effect of povidone iodine ointment against skin toxicity caused by sulphur and nitrogen mustard. Mechlorethamine hydrochloride 55867 m3978 spectrum. One reagent lane fair lawn, nj 07410 for information in north america, call. Mar 04, 2019 mechlorethamine hydrochloride pharmacokinetics absorption bioavailability.
In these patients, no detectable plasma mechlorethamine concentrations were found in blood samples obtained after 1 day and 1. Valchlor mechlorethamine topical dosing, indications. Decompostion may be initiated by action of localized heat. Nmethylbis2chloroethylamine hydrochloride company identification. Mechlorethamine hcl is designated chemically as 2chloron2chloroethyln. Mechlorethamine is a nitrogen mustard dna alkylator that binds and alkylates the n7 nitrogen on guanine and adenine bases in dna. Topics az slideshows images quizzes supplements medications. Product name mechlorethamine hcl product number fm15516 synonyms. Nitrogen mustard a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative. The ideal choice for forensic and toxicology testing. Identification of the substancepreparation and of the. Mechlorethamine hydrochloride monograph for professionals. Coa, qc data and msds documents are available in one week after order is received.
Side effects of mustargen mechlorethamine hcl, warnings. Mechlorethamine hydrochloride, chloromethine hydrochloride, mustargen. Mechlorethamine is the prototype of alkylating agents, it works by binding to dna, crosslinking two strands and preventing cell duplication. Dec 15, 2017 mustargen mechlorethamine hcl is a cancer antineoplastic medication used to treat several types of cancer, such as hodgkins disease, lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, lung cancer and mycosis fungoides. Stable if stored in accordance with information listed on the product insert. Keep mechlorethamine gel away from your eyes, nose, and mouth. Mechlorethamine hydrochloride can cause fetal harm when administered to a pregnant woman. If mechlorethamine gel gets in your eyes, it can cause eye pain, burning, swelling, redness, sensitivity to light, and blurred vision. Mustargen mechlorethamine hcl should be administered only under the. Mechlorethamine must be handled and used with great care since it may cause severe damage if it touches your skin, or gets in your mouth, nose, or eyes. This document has been prepared in accordance with.
The picture shown in the bottom panel is a sobering illustration of the toxicity of these compounds, depicting british soldiers suffering the effects of mustard gas. Mechlorethamine hydrochloride cas 55867 1 carcinogenic to humans. In these patients, no detectable plasma mechlorethamine concentrations were found in blood samples obtained after 1 day and 1 month of topical use. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. The hydrochloride is used as an antineoplastic in hodgkins disease and lymphomas. Sigmaaldrich offers a number of mechlorethamine hydrochloride products. Relevant identified uses of the substance or mixture and uses advised against identified uses laboratory reagent.
Terms of access to pfizer s safety data sheets for its products pfizer develops safety data sheets sdss for our products to help our employer customers occupational health and safety specialists assure workplace safety and comply with applicable laws. Not classified hydrochloric acid, 37% ww 7647 01 0 ld50 oral rat 700 mgkg ld50 dermal rabbit 5010 mgkg. Valchlor mechlorethamine gel is an alkylating drug indicated for the topical treatment of stage ia and ib mycosis fungoidestype cutaneous tcell lymphoma mfctcl in patients who have received prior skindirected therapy. Mechlorethamine hydrochloride mechlorethamine hydrochloride. Side effects of mustargen mechlorethamine hcl, warnings, uses. If you accept without changing your settings, we assume that you are happy to receive all cookies on the lgc website. Bis2chloroethylmethylamine hydrochloride 1,5dichloro3methyl3azapentane hydrochloride. Mechlorethamine may also be used for purposes not listed in this medication guide.
Niosh list of antineoplastic and other hazardous drugs cdc. Possibility of hazardous can react vigorously, violently or explosively with incompatible materials listed above. Please refer to its msds for proper handling and disposal. Hydrogen chloride, hcl recommended use laboratory chemicals. For research use only, not for human or veterinary use.
Chlormethine inn, ban, also known as mechlorethamine usan, usp, mustine, hn2, and in postsoviet states embikhin, is a nitrogen mustard sold under the brand name mustargen. Malignant pleural effusion, malignant pericardial effusion, and malignant peritoneal effusion. Check the msds or the proper handling section of the. Mechlorethamine is a bifunctional alkylating agent which forms inter and intrastrand dna crosslinks that cause the inhibition. Information on toxicological effects likely routes of exposure. It works by binding to dna, crosslinking two strands and preventing cell duplication. Mechlorethamine hydrochloride, 98% catalog numbers.
We prepare, maintain, and provide the sdss pursuant to applicable laws based on available information. We use cookies to ensure that we give you the best experience of our website. Dailymed valchlor mechlorethamine hydrochloride gel. Current shipping out time is about 2 weeks after order is received. Safe handling of hazardous chemotherapy drugs in limited. Mechlorethamine gel should only be used on the skin. Mechlorethamine was undetectable in plasma following topical administration of mechlorethamine 0. Therefore, it should be borne in mind that use of the drug may predispose the patient to bacterial, viral or fungal infection. Mechlorethamine hydrochloride pharmacokinetics absorption bioavailability. Mechlorethamine is used to treat the symptoms of several types of cancer. Mechlorethamine hydrochloride is approved to be used for palliative treatment of. Mustargen mechlorethamine uses, side effects, dosage. Certificate of analysis coa raman ftir pdf similar products. The solution should be freshly prepared just prior to use.
It may also cause blindness and permanent injury to your eyes. Mustargen 741793x mechlorethamine hcl 3 mustargen has been reported to have immunosuppressive activity. Mechlorethamine hydrochloride was used in a fluorescencebased apurinicapyrimidinic site cleavage assay for the identification of apurinicapyrimidinic endonuclease inhibitors in human cells. Buy mechlorethamine hydrochloride mechlorethamine hydrochloride from abmole bioscience. Msds mechlorethamine hydrochloride, 98% cas 55867 msds n. Mechlorethamine hydrochloride for injection uspstore below 40 c 104 f, preferably between 15 and 30 c 59 and 86 f.
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